Journal of Basic & Clinical Medical Sciences2959-92022959-92102022-09-134210610710.58398/0002.000031articleHira KhanNishtar Medical University, Multan, PakistanInfluenza vaccination is usually recommended as a clinical protocol for heart failure (HF) and chronic obstructive pulmonary disease (COPD) patients, primarily because they are at increased risk of infection, prolonged hospitalization, and death. However, despite international guidelines for annual immunization, vaccine coverage in Pakistan is unsatisfactory. international scientific evidence has reported that influenza vaccination is effective at reducing exacerbation, hospital admissions, and mortality among HF and COPD patients. However, in Pakistan, low influenza vaccine coverage is a result of limited vaccine awareness among patients as well as healthcare providers, vaccine hesitancy, patients’ financial constraints, and the absence of structured influenza vaccination programs by the government for such groups, all of which contribute to increases in preventable morbidity and mortality and add pressure on the healthcare delivery system of the country. Improving vaccination coverage would require a coordinated and intersectoral approach across the country.