Journal of Social & Health Sciences2959-96602958-65262022-09-153495710.58398/0001.000018articleZunaira ParveenMaryam AltafNimra RuddatRahila MushtaqNaeema BibiSheikha Fatima Institute of Nursing and Allied Health Sciences, PakistanSheikha Fatima Institute of Nursing and Allied Health Sciences, PakistanSheikha Fatima Institute of Nursing and Allied Health Sciences, PakistanSheikha Fatima Institute of Nursing and Allied Health Sciences, PakistanDHQ Hospital Timergara, PakistanEffective pain management is a cornerstone of quality nursing care, yet knowledge gaps and systemic barriers often hinder optimal practice, particularly in low-resource settings. This study aimed to assess nurses’ knowledge and attitudes regarding pain management, evaluate their self-reported pain practices, and explore the role of perceived organizational support in shaping pain management competence among nurses in a tertiary care hospital in Lahore, Pakistan. An exploratory survey was conducted with 120 registered nurses using the Knowledge and Attitudes Survey Regarding Pain (KASRP), a perceived organizational support scale, and a self-reported practice checklist. Descriptive statistics revealed that only 22.5% of the nurses reported good knowledge, whereas 45% reported moderate knowledge, and 32.5% reported poor knowledge. Perceived organizational support was moderate on average, and although self-reported practice scores were relatively high, they did not significantly correlate with knowledge levels. The Mann–Whitney U test revealed no significant differences in knowledge or practice scores by sex. Spearman correlation analysis revealed a significant positive association between organizational support and knowledge scores. Multiple linear regression identified organizational support as the only significant predictor of knowledge scores (p = 0.003). These findings highlight the critical role of organizational factors in fostering clinical competence and suggest the need for system-level interventions—such as regular training, managerial support, and access to protocols—to improve pain management outcomes in nursing practice.